For pancreatic carcinoma, several researches have demonstrated that TIL-Bs in supporting both early and more advanced stages of pancreatic tumorigenesis by multiple mechanisms, including suppression of other immune cells (e.g., CD8+ T cells and macrophages) in the tumor microenvironment and promoting pancreatic cancer cell proliferation (96). The gene discussed is CD8A; the disease is exocrine pancreatic carcinoma.