The top 10 mutation genes in the LR group are TTN (28%), CTNNB1 (24%), MUC16 (20%), AHNAK2 (16%), CACNA1E (16%), CSMD1 (16%), FCGBP (16%), ABCA13 (12%), ADGRV1 (12%), and COL11A1 (12%) (Figure 1A), which were different from the NR-HCC, TP53 (33%), CTNNB1 (20%), TTN (20%), CSMD3 (15%), BAP1 (13%), MUC16 (13%), RYR1 (13%), AXIN1 (11%), CCDC168 (11%), and FAT4 (11%) (Figure 1B). The gene discussed is RYR1; the disease is hepatocellular carcinoma.