LGALS1 and colorectal carcinoma: Indeed, we found that fibroblast-secreted Gal-1 enhanced EMT-related gene expression in vitro in CRC cells, and increased the number of injected human CRC cells in the lungs in both short-term and long-term in vivo mouse models (Figures 2C, D and 3C, D); moreover, high expression of Gal-1 in CRC patients correlated significantly with metastasis and recurrence (Figure 3E).