LGALS1 and colorectal carcinoma: To assess for clinical relevance, we analyzed the human CRC transcriptome databases which contain recurrence information (GSE33113 and GSE17536; Supplementary Table S2) and found that high expression levels of LGALS1, but not β-catenin (CTNNB1), correlate significantly with a high risk of metastasis and/or recurrence within 3 years (Figure 3E).