To further explore the potential of prostate sectional area related predictors to predict PCa, we built new predictors like PAI, PSAPA, PSACGA, and PSAPZA (calculated by PZA/CGA, PSA/PA, PSA/CGA, and PSA/PZA) based on the sectional area from three different directions in MRI segments. Here, KLK3 is linked to posterior cortical atrophy.