IL6 and lung adenocarcinoma: To explore whether the changing trend of IL-6 level in lung adenocarcinoma from public databases is the same as our experimental result, we queried the mRNA expression of IL-6 in The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO, GSE40419)dataset—whose samples are also tissues rather than serum—and found a consistent result that the IL-6 is down-expressed in lung adenocarcinoma, where P value equals to 7.21e-26 and 4.29e-07, respectively (Figure 2B and Supplementary Table S2).