STAT3 and lung cancer: As for lung cancer, IL-6 was thought to promote cancer malignancy with the functions in migratory, chemotactic, and angiogenetic properties of cancer cells by USP24 (27); microRNA-218, a down-regulated miRNA that targets the IL-6/STAT3 pathway, was illustrated to suppress lung cancer (28); meanwhile, IL-6 blockade could reduce tumorigenesis in a kind of LUAD mouse model (29).