Through the whole research process, we mainly drew two main conclusions: First, in the microenvironment of lung adenocarcinoma tissue with early lesions of GGO, IL-6 and NK cells showed a consistent decrease; Second, the decrease of NK cells is correlated with IL-6, and the proliferation or activation of NK cells can be stimulated by increasing IL-6 in the GGO tumor microenvironment. This evidence concerns the gene IL6 and lung adenocarcinoma.