To further reveal whether these involved mechanisms mentioned before also are related to IL-6 and NK cells in early lung adenocarcinoma with GGO or not, we then compared the expression of seven genes (IL-6, CD16, CD56, PD-1, PD-L1, JAK1, and STAT3) with 25 pairs of early lung adenocarcinoma samples by quantitative real-time PCR (qPCR) (Figure 5A and Supplementary Table S4) and analyzed their expression data in RNA-seq (Figure 5B and Supplementary Table S5). The gene discussed is CD274; the disease is lung adenocarcinoma.