This visual summary shows that lnc-KASRT located on SRSF1, interacts with SRSF1, then regulates alternative splicing of KLF6 to promote KLF6-SV1 coding while inhibiting KLF6-WT coding, and subsequently modifies P21/CCND1 pathway, finally leading to increased growth and invasion of osteosarcoma. This evidence concerns the gene SRSF1 and osteosarcoma.