found that VPA inhibited the Akt/mTOR pathway by reducing the expression of p-Akt/AKT and p-mTOR/mTOR in glioma cell lines U251 and SNB19 (13), while in the study conducted by Zhang et al., VPA could increase the phosphorylation of ERK and Akt in the ERK/Akt pathway in U87 (17). Here, MTOR is linked to central nervous system cancer.