A small region of AAV2, including the 3’-inverted tandem repeat region, when integrated in proximity of cancer genes such as telomerase reverse transcriptase (TERT), cyclin A2 (CCNA2), cyclin E1 (CCNE1), and tumor necrosis factors (ligands) superfamily, can induce gene expression and promote cell proliferation and malignant transformation (16). The gene discussed is CCNA2; the disease is cancer.