In this study, we found that along with the decrease in proliferation and increase in apoptosis, the expression of PSEN1 was upregulated in U251/LN229 cells and xenograft tumor intervened by SCU and its combination with C18H17NO6, suggesting that this drug combination might promote glioma apoptosis and enhanced the sensitivity of glioma to the drugs themselves by upregulating PSEN1. The gene discussed is PSEN1; the disease is central nervous system cancer.