AKT1 and central nervous system cancer: Since PSEN1 inhibited cell proliferation and induced apoptosis by suppressing phosphatidylinositol 3−kinase/protein kinase B (PI3K/AKT) signaling (26, 27), we further explored whether PI3K/AKT signaling was involved in the inhibitory effect on glioma by scutellarin and C18H17NO6.