GNA11 and esophageal squamous cell carcinoma: In this validation cohort, the level of anti-GNA11 autoantibody was distinctly higher in the ESCC group (mean ± SD: 0.345 ± 0.068) than that in the normal control group (mean ± SD: 0.281 ± 0.079) (Figure 3C), and the AUC value was as high as 0.751 with sensitivity of 38.24% and specificity of 88.82% (Figure 3D).