GNA11 and esophageal squamous cell carcinoma: In the verification cohort (73 ESCC vs. 73 NC), a higher expression level of anti-GNA11 autoantibody was observed in ESCC patients (mean ± SD: 0.301 ± 0.054) compared with normal controls (mean ± SD: 0.277 ± 0.049) (Figure 3A); and anti-GNA11 autoantibody can distinguish 10.96% of ESCC patients with an AUC of 0.653 at the specificity of 98.63% (Figure 3B).