Another study indicated that hotspot mutations of Gαq and Gα11 (R183 and Q209) that occurred in uveal melanoma acting as cancer driver genes will destroy the function of GTPase in the MAPK/MEK/ERK pathway, and the implementation of GNAQ/GNA11 mutation analysis in clinical diagnosis processes might be helpful in making treatment decisions (37). This evidence concerns the gene GNA11 and uveal melanoma.