METTL3 and acute lymphoblastic leukemia: In summary, our results suggest that polymorphisms rs1263801 C>G, rs1139130 A>G, and rs1061027 A>C in the METTL3 gene were significantly associated with increased pediatric ALL risk, and SCCLG chemotherapeutics is more suitable for rs1263801 CC and rs1139130 AA carriers; CCCG chemotherapeutics is more efficient for rs1061027 AA carriers in the Southern Chinese ALL children.