A literature search was conducted using PubMed and Google Scholar from January 1980 to June 2020 using the following search terms: ACE inhibitors, lisinopril, enalapril, fosinopril, trandolapril, ramipril, perindopril, captopril, benazepril, ambulatory blood pressure, hypertension, twice-daily dosing, once-daily dosing. Here, ACE is linked to Hypertension.