Hematopoietic functions in baseline were evaluated before treatment for every patientProphylactic use of filgrastim (G-CSF) or sargramostim (GM-CSF) is recommendedIn addition to bone marrow suppression, splenomegaly and hypersplenism should be focused on, and local treatment of the spleen if necessaryDose adjustment of chemotherapeutic drugs is required for grade 4 neutropeniaOccurrence of febrile neutropenia requires dose adjustment and therapeutic antibiotics for infections. This evidence concerns the gene CSF2 and Splenomegaly.