TNF and Graves disease: The tumor necrosis factor-alpha (TNF-α) rs1800629 polymorphism was reported to exhibit a 1.97-fold association with hyperthyroidism (95% confidence intervals = 1.27–3.06, P=0.002) in 2,790 Graves' disease patients and 3,472 healthy controls, but subgroup analysis revealed a genetic impact on Europeans and not in Asians [11].