More specifically, genetic risk factors of Graves' disease accompany having the risk alleles of HLA-DR3, a cluster of differentiation 152 (CD152 or CTLA4), protein tyrosine phosphatase nonreceptor type 22 (PTPN22), CD40, interleukin (IL)-2 receptor alpha chain (IL2RA), IL-23 receptor (IL23R), and Fc receptor-like 3 (FCRL3) [7]. This evidence concerns the gene CTLA4 and Graves disease.