CFTR and cystic fibrosis: Gale, Sheppard, Davis and co-workers have highlighted the real potential of anionophores as cystic fibrosis treatments by demonstrating that carriers, based on trans-decalin scaffolds bearing thiourea groups, mediate anion transport in yellow fluorescent protein (YFP)-modified cystic fibrosis airway epithelial cells.184 These experiments also showed that the anionophores were additive with the activity of known cystic fibrosis transmembrane regulator (CFTR) pontentiator ivacaftor and cystic fibrosis corrector lumacaftor, both of which are already used in the clinic.