Recently, Peng et al. evaluated the neuroprotective effects of onjisaponin B using MPTP-induced subacute PD mice, and found that it improves motor impairment, attenuates microglia overactivation, and reduces the production of inflammatory factors including TNF-α, IL-1β, and IL-6 [186] (Figure 3). Here, IL1B is linked to Parkinson disease.