SNCA and Parkinson disease: In 2020, Park et al. reestimated the neuroprotective effects of GP-EX on an A53T α-synuclein transgenic mouse model of PD (A53T mice), and found that GP-EX obviously reversed the increased α-synuclein-immunopositive cells and α-synuclein phosphorylation in the midbrain of A53T mice [162].