Ethanol extract of AOF was reported to restore 6-OHDA-induced dopaminergic neuron degeneration and attenuate a deficit of locomotor activity in a zebrafish model of PD by alleviating inflammation (downregulation of IL-1β and TNF-α expression) and oxidation (inhibition of NO production) stress [115] (Figure 3). Here, IL1B is linked to Parkinson disease.