There is increasing evidence that links the nucleotide-binding and leucine-rich repeat pyrin domains protein 3 (NLRP3) inflammasome and its stimulation of cytokine secretion with the pathogenesis of various cardiovascular diseases, including atherosclerosis, acute myocardial infarction (AMI), acute myocarditis, and progression to heart failure (HF). Here, NLRP3 is linked to cardiovascular disorder.