Levels of ANP and BNP were lower in the NR+TAC group compared with the TAC group (ANP: 1.32 ± 0.08 vs. 1.76 ± 0.06; P < 0.05; BNP: 1.74 ± 0.05 vs. 2.31 ± 0.06; P < 0.05), indicating that NR treatment significantly improved the myocardial hypertrophy induced by TAC (Figure 1(d)). This evidence concerns the gene NPPA and cardiac hypertrophy.