A study on 273 patients showed that the upregulation of PD-L1 and mPD-L1 expression in DLBCL cells was significantly associated with non-GCB type and EBV positively, and these patients had a lower OS than DLBCL patients with downregulated PD-L1 expression [41, 44, 45]. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.