Finally, our study compares somewhat subjective IHC interpretation results to Oncotype DX molecular results as well as to the Oncotype DX cutoffs for positive expression of HER2, ER and PR which were established based on validation against IHC results from hundreds of breast cancer specimens from clinical trials that may not match the demographic and socioeconomic characteristics of our sample population [20, 21]. The gene discussed is ERBB2; the disease is breast carcinoma.