In summary, based on the previous work, our present study further demonstrated that TXL could protect ischemic brain tissues against pyroptotic cell death and pyroptosis-related neuroinflammation, inhibit astrocytic pyroptosis by inactivating caspase-11/GSDMD, and reduced toxic Aβ accumulation around astrocytes in cerebral I/R injuries, and thus potentially contribute to the prevention and treatment of poststroke dementia. This evidence concerns the gene GSDMD and dementia.