In a clinical meta-analysis of 8097 patients, we found a genotypic and phenotypic association in patients with DCM, including a higher prevalence of sudden cardiac death (SCD), heart transplantation, or ventricular arrhythmias in patients with LMNA and PLN mutations compared to those with segmental gene mutations [10]. The gene discussed is PLN; the disease is familial dilated cardiomyopathy.