For treatment of low-risk uncomplicated hypertension grade 1 patients, as well as hypertension and coronary artery disease or frail older patients, ESC Guidelines and National consensus recommended as first-line monotherapy one of the followed group medicines: ACE-inhibitors, ARB (sartans), CCB, diuretic or beta-blocker, followed by their combinations, as a second treatment step (except combination between two ARBs).Beta-blockers should be considered if there is a specific indication for their use (24, 25). This evidence concerns the gene ACE and Hypertension.