Topical administration of onion extract on nasal cavity mice model of allergic rhinitis caused a reduction of allergic symptom score, serum levels of total and ovalbumin (OVA)-specific IgE, cytokine levels of nasal mucosa including IL-4, IL-5, IL-10, IL-13, IFN-γ, TNF-α and COX-2 and eosinophilic infiltration. The gene discussed is IL4; the disease is allergic rhinitis.