It is possible that the leukemic microenvironment and even the leukemic cells themselves cause decreased expression of TLR activators in NK cells through a mechanism similar to that described by Rouce et al. [12] where it has been shown that leukemia cells induce the TGF-β/SMAD pathway in NK cells of leukemic patients, causing their dysfunction and low cytotoxic activity. This evidence concerns the gene TGFB1 and leukemia.