PD-L1 overexpression is more common in esophageal squamous cell carcinoma (ESCC) (41%), compared with gastric adenocarcinoma (GAC) (10%), esophageal adenocarcinoma (EAC) (9%), and gastroesophageal junction adenocarcinoma (GEJAC) (8%), while high microsatellite instability (MSI-H) and high tumor mutational burden (TMB-H) are rare in gastroesophageal cancer [13]. This evidence concerns the gene CD274 and esophageal squamous cell carcinoma.