As an important factor involved in cell life activities, CBX8 inhibits the transcription of some critical target genes, including the INK4a/ARF gene (a tumor-suppressing gene affecting the survival of cells) (Dietrich et al., 2007) and the AF9 gene (related to acute leukemia occurrence) (Tan et al., 2011), and can regulate cell differentiation (Tang B. et al., 2019). Here, CDKN2A is linked to neoplasm.