Although the differences in CBX8 expression between PAAD and normal tissues was not observed in the TCGA project (tumor:178 cases, normal:4 cases) (Figure 1A), we found significant differences by combing the TCGA normal and GTEx (tumor:179 cases, normal:171 cases, P-value < 0.001) (Supplementary Figure 3B). Here, CBX8 is linked to neoplasm.