AKT1 and cancer: Furthermore, KEGG pathway analysis showed that the significantly enriched genes were for small cell lung cancer, miRNAs in cancer, PI3K–Akt signaling pathway (Cheng et al., 2015), Ras and p53 signaling pathways (Vescovo et al., 2016), cellular senescence (Shiu et al., 2017), endocrine resistance, and advanced glycation end products (AGE)–receptor for AGE (RAGE) signaling pathway in diabetic complications (Hyogo and Yamagishi, 2008; Figure 4B and Supplementary Table 4).