Since IGF1 and BMR are highly correlated exposures, where IGF1 can affect BMR (Swanson and Dantzer, 2014), we conducted multivariable MR to take into account the effect of GVs on cancer via IGF1 by adjusting for IGF1 (Burgess and Thompson, 2015; Sanderson et al., 2019), and the results were consistent. Here, IGF1 is linked to cancer.