MAPK1 and lung carcinoma: For example, circRNA hsa_circ_100395 has been demonstrated to inhibit lung cancer progression by regulating the miR-1228/TCG21 pathway (Chen et al., 2018), while circRNA_101237 promotes NSCLC progression by regulating the miR-490-3p/MAPK1 axis (Zhang Z. Y. et al., 2020).