In KEGG pathway analysis, some classical pathways, such as the PI3K-Akt, MAPK, cAMP, mTOR, and Hippo signaling pathways (Assenza et al., 2018; Luo et al., 2018; Romano, 2019; Rowton et al., 2021), have been previously implicated in CHD, which indicates the reliability of our experimental data. This evidence concerns the gene AKT1 and coronary artery disorder.