The in silico analysis of pathways affected by the regulatory activity of down-regulated miRNAs identified by our research has risen some significant queries that need to be further examined, most notably the inference of miRNA sequencing data in F0104 males, a suitable translational model for studying the unpredictable collateral effects of excess GH on reproductive traits especially on the pathophysiology of male infertility by unknown, apparent cause. Here, GH1 is linked to male infertility.