MAP3K8 and nonpapillary renal cell carcinoma: To better understand the important roles of MAP3K8 methylation in oncogenesis and progression, we explored methylation levels of MAP3K8 in different ccRCC samples, including tumor status (normal and tumor), patient race (Caucasian, African-American, and Asian), gender (male and male), patient age (21–40, 41–60, 61–80, and 81–100 years), tumor grade (Grade 1, Grade 2, Grade 3, and Grade 4), and metastasis status (N0 and N1).