To comprehensively investigate the mutation profile of MAP3K8 across all TCGA cancers, TIMER2.0 and DriverDBv3 were used, suggesting that MAP3K8 mutation is rare among most cancers with frequencies ranging from 0.1% (1 of 500 THCA patients) to 4.5% (24 of 531 UCEC patients) (Supplementary Figure 2). Here, MAP3K8 is linked to cancer.