Moreover, studies have found that anti-tumor cytotoxicity of T lymphocytes could be promoted in cancer patients through activation of TLR-mediated MAPK and NFKB signaling pathways (Chen Y. et al., 2017), suggesting whether TLR pathway regulates functions of TILs via MAP3K8 cascades need to be further studied. This evidence concerns the gene NFKB1 and cancer.