CD4 and cancer: On one hand, ccRCC patients with high-level expression of MAP3K8 negatively correlated with the presence of T cell CD4+ Th1, non-regulatory T cell CD4+, and NK cell, suggesting a potential protumorigenic role of MAP3K8 because CD4+ TILs and NK cells were reported to associate with better OS in cancers (Hao et al., 2020).