Apart from standard criteria, other non-criteria clinical and laboratory features have been found associated with APS in numerous studies, such as heart valve disease, thrombocytopenia, neurological manifestations, anti-CL or anti-β2GpI IgA, anti-phosphatidylserine–prothrombin (aPS/PT) complex, and anti-annexin A5 antibodies (aAnxV) (4, 5). This evidence concerns the gene CD79A and autoimmune polyendocrinopathy.