Among 151 APS patients, cross-positivity of IgG, IgM, or IgA for aCL or aβ2GpI (a and b), as well as IgG or IgM for each of the four aPLs (c and d) were demonstrated with the Venn diagram in Figure 2. The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.