The 2006 APS classification criteria (Sydney criteria) have been widely accepted in APS diagnosis, where at least one of the clinical criteria, as well as one of laboratory criteria including lupus anticoagulant (LA), high level of anti-cardiolipin (aCL), and anti-β2 glycoprotein-I (aβ2GPI) immunoglobulin isotype G (IgG) or M (IgM), should be present (1). The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.