Dsg3 and Dsg1 are the major target antigens in pemphigus, but in the last 20 years, new relevant findings have demonstrated the role of non-Dsg autoantibodies in pemphigus cell-cell detachment (3, 4) even acting synergistically when Dsg autoantibodies are absent (5). The gene discussed is DSG3; the disease is pemphigus.