We should consider the presence of anti-Dsc antibodies in different circumstances: clinical features of PH, PVeg or atypical pemphigus; presence of pustules; classical pemphigus patients without detectable anti-Dsg antibodies; intraepithelial neutrophils/eosinophils or dermal neutrophilic/eosinophilic infiltrate on histological examination, and dual pattern DIF examination. Here, DSG1 is linked to pemphigus.