A wide range of diffusible mediators released from transformed or non-transformed cells in the tumor niche are known to induce EMT, including growth factors (EGF), cytokines (TGF-β, TNF-α), chemokines (CXCL8, CXCL6), and lipid mediators (leukotriene B4 (LTB4)) (48, 49). The gene discussed is TGFB1; the disease is neoplasm.