For instance, secretion of CXCL8, IL-1β, LIF (leukemia inhibitory factor), and Fam3 (family with sequence similarity 3 member C) were found elevated or impaired in a murine melanoma cell line when stimulated with an autophagy-inducing peptide or subjected to autophagy related gene knockdown approaches, respectively (90). This evidence concerns the gene LIF and melanoma.