STAT3 and neoplasm: Upon HCMV infection of human cancer stem cells and in the presence of cmvIL-10, cancer stem cells can induce macrophage reprogramming “M2 phenotype” in the tumor microenvironment hence favoring the appearance of tumor-associated macrophages (TAMs) and enhancing other immunomodulatory, oncogenic, and angiogenic cytokines’ expression such as STAT3 and vascular endothelial growth factor (VEGF) (146–148).