SOX2 and glioblastoma: Studies reveal the effect of HCMV-IE1 protein in promoting the preservation of glioblastoma cancer stem cells through its induction of SRY-Box Transcription Factor 2 (SOX2), Nanog, Nestin, and octamer-binding transcription factor 4 (OCT3/4) where it’s considered as a key regulator of glioblastoma stem-like phenotype (134).