Upon HCMV infection of human cancer stem cells and in the presence of cmvIL-10, cancer stem cells can induce macrophage reprogramming “M2 phenotype” in the tumor microenvironment hence favoring the appearance of tumor-associated macrophages (TAMs) and enhancing other immunomodulatory, oncogenic, and angiogenic cytokines’ expression such as STAT3 and vascular endothelial growth factor (VEGF) (146–148). This evidence concerns the gene VEGFA and cytomegalovirus infection.