In addition, another recent evidence (86) confirmed that the expression of inhibitory receptors on the surface of CD4+ and CD8+ T cells, such as PD-1, T-cell immunoglobulin and mucin-domain containing-3 (TIM3), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), was higher in the tumor tissue than that in the non-tumor tissue and peripheral blood. The gene discussed is CTLA4; the disease is neoplasm.