CD8A and hepatocellular carcinoma: Based on immunohistochemistry staining for CD8+ TILs from 29 cases with HCC, Yarchoan’s team found that the expression of CD8+T cells in the tumor tissue was remarkably lower than that in the liver background, and the expression of CD8+ T cells in the tumor side was lower than that in the nontumor side of tumor interface (36).