Low Foxp3+/CD3+, Foxp3+/CD4+, Foxp3+/CD8+TIL ratio, and high CD4+/CD8 +TIL ratio were shown to correlate with good prognosis (Figure 1), while CD8+/CD3+TIL ratio showed no correlation with survival in HCC (12, 52–54). This evidence concerns the gene CD8A and hepatocellular carcinoma.