With the knowledge that CD49a similarly defines polyfunctional TRM in human skin and tumor infiltrating lymphocytes in melanoma, and supports cell motility, we propose that the ubiquity of collagen IV in the basement membrane of epithelial surfaces and the data presented here, further substantiate a probable role for CD49a in many, if not all TRM populations (13, 26). Here, ITGA1 is linked to neoplasm.