In addition, inhibition of matrix metallopeptidase 13 (MMP13)-mediated phosphorylation of eIF4B (Ser422) reduces the protein synthesis of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and amyloid-β accumulation, which contributes to the improved learning and memory in the animal model of Alzheimer’s disease (30). Here, MMP13 is linked to early-onset autosomal dominant Alzheimer disease.