EIF4B and early-onset autosomal dominant Alzheimer disease: Therefore, dysregulation of eIF4B protein expression or its phosphorylation is associated with the development and progression of numerous human diseases including Alzheimer’s disease (30), diffuse large B-cell lymphoma (DLBCL) (31, 32), T-cell lymphoblastic leukemia (33), acute myeloid leukemia (34), Abl-positive CML (24), breast cancer (35, 36), and hepatocellular carcinoma (25, 37).