NFKB1 and Sepsis: Alternatively, Ori also exerts considerable anti-inflammatory activity by inhibiting the activation of NF-κB and/or MAPK, resulting in the suppression of the release of proinflammatory cytokines including interleukin (IL)-6 and tumor necrosis factor (TNF)-α (9–11) in colitis, sepsis, and neuroinflammation (12–15).