LAMP3 and neoplasm: This immune-suppressive transcriptomic pattern in LAMP3+ DCs has been widely detected in various tumors by scRNA-seq, including in bladder urothelial carcinoma (128), hepatocellular carcinoma (129, 130), and lung cancer (119, 131), suggesting that universal crosstalk fosters an immune-suppressive niche for the tumor microenvironment.