Based on scRNA-seq analysis on experimental melanoma mouse models, Lelliott et al. (136) showed that combined BRAF, MEK, and CD4/6 inhibition triple therapy could result in the marked depletion of cDC1s from the tumor milieu, the absence of which might contribute to non-response to ICB and poor survival in patients with melanoma. Here, MAP2K7 is linked to melanoma.