Immunohistochemistry (Figure 2C): tumor cells CD21 (+, partial), CD23 (+ partial), CD35 (weak positive), sstr-2 (+, partial), CD163 (+ partial), cd68/pgm-1 (+, focal area), HMB45 (–), PCK (–), ALK (–), LCA (–), EMA (–), STAT-6 (–), syn (–), TLE (–), DOG-1 (–), SDHB (without delated), CD117 (–), DES (–), CD34(-), SMA (–), S100 (–), Ki-67 (+, 10% - 20%), in situ hybridization EBER1/2 (–), PD-1 (–), and PD-L1 (+90%) (Figure 3). The gene discussed is CD274; the disease is neoplasm.