CCL22 secretion also enables the attraction of pro-tumor immunosuppressive cells via interactions with CCR4 receptors on the surface of Th2/Treg cells, while autocrine generation of CXCL12 was shown to support tumor growth and metastasis (42) and modulate the differentiation of monocytes into a phenotype with immunosuppressive and proangiogenic characteristics (93). This evidence concerns the gene CXCL12 and neoplasm.