Altogether, the combined effect of IL-4, IL-13, IL-10, TGFβ and CCL2 resulted in the induction of a spectrum of M2a/c microglia phenotypes with capabilities for inducing matrix deposition, ECM-remodeling and angiogenic processes, and overall, a tumor-supportive niche that facilitates growth and invasion. The gene discussed is IL13; the disease is neoplasm.