Our recent evidence shows that SARS-CoV-2 ORF9b can also target the NF-κB essential modulator NEMO upon viral infection and inhibits its K63-linked ubiquitination, thus disrupting the canonical IKKα/β/γ-NF-κB signaling and subsequent IFN production (Wu et al., 2021). This evidence concerns the gene NFKB1 and viral infectious disease.