Two genes that are upregulated by this transcriptional program are MDM2, which promotes p53 proteasomal degradation, and lysine-specific histone demethylase 1A (LSD1), which is necessary for maintaining plasticity and proliferative capacity of MCC cells (Park et al., 2019, 2020; Leiendecker et al., 2020). Here, TP53 is linked to Merkel cell skin cancer.