M. leprae genes encoding laminin-2 binding protein ML1683c and the six enzymes (ML0128, ML2348 ML0126, ML0127, ML23246c, and ML2347) required to produce the terminal trisaccharide moiety of phenolic glycolipid 1 (PGL-1) are highly conserved in M. lepromatosis (Singh et al., 2015), suggesting likely anti-PGL-1 seropositivity in M. lepromatosis HD cases and nerve involvement and damage through invasion of Schwann cells (Ng et al., 2000). The gene discussed is SDHD; the disease is Huntington disease.