Hyperprolactinemia is a high level of serum prolactin, which can interfere with the periodic release of GnRH, the elimination of gonadotropin pulsed secretion, so that the release of LH and FSH decreased, eventually leading to hypogonadism (testosterone synthesis and secretion, spermatogenic dysfunction) (37). This evidence concerns the gene PLOD1 and hyperprolactinemia.