Central CH as part of CPHD may also present with hypoglycemia (due to ACTH ± GH deficiency), sepsis-like illness (ACTH deficiency), undescended testes/micro-penis (boys; LH&FSH deficiency), elevated liver enzymes (ACTH deficiency and TSH deficiency), and midline defects associated with CPHD. Here, POMC is linked to central congenital hypothyroidism.