TPO and anti-thyroglobulin antibodies were strongly associated with the presence of autoimmune disease in persons with DS/MMS (p < 0.001, 95%CI: 2.46–44.8) and DS (p < 0.001, 95%CI: 3.56–11.4) but not MMD (p = 0.44, 95%CI:0.4–35.4). This evidence concerns the gene TG and autoimmune disease.