Other genes that may play critical roles in synaptic plasticity, including Rabs, synaptotagmins, Calcium/calmodulin-dependent protein kinase II (CaMKII), cAMP-responsive element-binding protein 1 (CREB1), oligodendrocyte-myelin glycoprotein (OMG), and Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1), could be regarded as candidate modifier genes of cognitive disorders (34, 39). This evidence concerns the gene CREB1 and cognitive disorder.